14 results
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Suspect: Clinical ... Malignancy (e.g. hematologic ... lymphoproliferative syndrome Clinical ... , APLA, PAC • Aseptic ... vein thrombosis Hematologic
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... erythematosus ( ... erythematosus ( ... erythematosus ( ... ANA #patterns #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus ( ... SLE) Clinical ... Seizure disorders, Aseptic ... Cerebrovascular Disease ... cerebritis #diagnosis #management
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... of Systemic Lupus ... of hip (rare), Arthritis ... pain (20%) Renal disease ... SLE #systemic #erythematosus
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... 40, F:M 9:1 • Clinical ... Evolution: Chronic disease ... #Systemic #Erythematosus ... #Summary #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Systemic lupus ... erythematosus ... brucellosis) • Sepsis ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Differential Diagnosis of Acute Arthritis

Crystal-induced arthritis: Calcium oxalate, gout, cholesterol, pseudogout, hydroxyapatite crystals

Infectious arthritis: Bacteria, fungi,
sarcoid, systemic lupus ... erythematosus,* ... Still disease,* ... hyperlipoproteinemia,* meniscal ... Monoarticular #Septic
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad ... Fever, Arthralgia/arthritis ... splenomegaly • Hepatic ... #diagnosis #management ... #treatment #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Constitutional symptoms, Arthritis ... Erythematosus ( ... 40, F:M 9:1 • Clinical ... Evolution: Chronic disease
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
association • M > F Clinical ... erythema nodosum (septal ... Behcet syndrome (Clinical ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology