35 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
other autoimmune diseases ... with systemic diseases ... like rheumatoid arthritis ... Sjogrens #Syndrome #Pathophysiology ... #Diagnosis #Signs
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
Leukemia) • GI diseases ... liver or kidney disease ... Corticosteroid use • Primary ... #Osteoporosis #pathophysiology ... #signs #symptoms
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Primary Biliary ... quadrant discomfort Signs ... associated autoimmune disease ... Raynaud's phenomenon, arthritis ... of autoimmune disease
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Primary Hyperthyroidism ... rare, gestational diseases ... Signs/Symptoms: ... Pretibial myxedema #Primary ... endocrinology #pathophysiology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
skin injury) • Neurologic ... SLE, Reactive arthritis ... Ocular melanoma • Arthritis ... SLE, Reactive Arthritis ... diagnosis #management #signs
Lyme Disease: Early and Late Clinical manifestations
Stage 1. Localized
 • EM appears 7-14 days at the
Lyme Disease: Early ... • Heralded by neurologic ... years after • Arthritis ... WuidQ #Lyme #Disease ... #diagnosis #signs
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... 65 years PBC Pathophysiology ... failure PBC Signs ... but elevated as disease ... , IgG4 related disease
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
clots ➔ Lower Urinary ... basement membrane disease ... hematuria • Signs ... of glomerular disease ... Hematuria: • Urethritis
Clinical Manifestations and Diagnosis of Lyme Disease - Borreliosis
Erythema migrans
 - 3-32 days (median: 7-10 days)
Diagnosis of Lyme Disease ... findings, Lyme serology ... missing in early disease ... antibodies Lyme arthritis ... Borreliosis #Diagnosis #Signs
Giant Cell Arteritis (Polymyalgia Rheumatica and Cranial Arteritis): Pathogenesis and Clinical Findings
 - Morning Stiffness (>1
Giant Cell Arteritis ... Muscle Aching (Primarily ... Anemia of Chronic Disease ... CranialArteritis #Pathophysiology ... #Signs #Symptoms