36 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Idiosyncratic - less common ... Idiosyncratic #differential ... #Diagnosis #Management ... gastroenterology #hepatology
Hypocalcemia - Diagnosis and Management
PTH Independent (↑ PTH)
 • LOW VIT D
    -
and Management ... - Activation: Liver ... Iatrogenic (most common ... Radiation - Mg ... #differential #
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Bilirubin: <5 mg ... Bilirubin: <5 mg ... Disease #Pregnancy #hepatology ... hepatitis #comparison #differential ... #diagnosis #icp
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
• Incidence: common ... kg/day vs. 2.5 mg ... initiation • Differential ... q12h -> 10 mg q6h ... #management #hematology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
infiltration) Differential ... Diagnosis: Viral ... Maternal Support - Critical ... #Pregnancy #hepatology ... obstetrics #obgyn #diagnosis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE) - Diagnosis ... 40, F:M 9:1 • Clinical ... - Cytopenia: Common ... • Immunologic Workup ... #rheumatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
disease to acute liver ... arthralgias) are common ... hepatocellular pattern of liver ... Muscle Abs (ASMA) (common ... #Management #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Female:Male 9:1 • Common ... cholestasis → Cirrhosis/Liver ... or higher • Liver ... bile ducts Differential ... #workup #hepatology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... disease • Liver ... than 100 to 300 mg ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
The 6 C’s of Primary Sclerosing Cholangitis (PSC)
PSC is a chronic, cholestatic, immune-mediated disease characterized by
asymptomatic at diagnosis ... disease management ... remain subject to clinical ... #management #summary ... #Hepatology