11 results
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
= (Retic %) x (Hct ... long (in days) it ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... Production #Index #hematology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
to 280 U/L • It ... bloodstream Hemolysis ... : • Hemolytic ... deficiency of red blood ... The presence of macro-LDH
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Diagnosis: • hemolytic ... Immunoglobulin M (IgM) • Blood ... Mycoplasma, EBV, HIV ... sensitize red blood ... #anemia #hematology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... • Febrile Non-Hemolytic ... May have drop in Hct ... Extremely rare - HIV ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
- Acute Hemolytic ... Hemolysis on labs ... May have drop in Hct ... Extremely rare - HIV ... diagnosis #management #hematology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
Thrombocytopenia (HIT ... ♀, ↑Age, ESRD Pathophysiology ... false ⊕’s, so use Bayesian ... likelihood of HIT ... Management #Treatment #Hematology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Aseptic necrosis of hip ... Glomerulonephritis Myositis(5%) Blood ... normochromic nomocytic or haemolytic ... symptoms #diagnosis #rheumatology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
of high parity blood ... donor • Pathophysiology ... : 2 hit mechanism ... transfusion • Pathophysiology ... Transfusion #Reactions #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
ABO incompatible blood ... protein C and S Pathophysiology ... deficiency) • HIT ... treatment #management #hematology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
phosphate: Impairs Vit ... deficiency • blood ... collection with EDTA Pathophysiology ... pressure - Elevated Vit ... Hyophosphatasia #hepatology