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Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... Mechanical Trauma (Microangiopathic ... hemolytic anemia ... - Thrombotic microangiopathy ... Extravascular #Causes
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Immune mediated hemolysis ... Schistocytes DAT(-) → Microangiopathic ... hemolytic anemia ... Diagnosis #Algorithm #causes
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Causes of Hemolytic ... Environment - Microangiopathic ... Sophia_Hayes_MD #Hemolytic ... Differential #Diagnosis #Causes
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Bleed • Hemolysis ... Fragments • Microangiopathic ... Hemolytic Anemias ... Diagnosis #Algorithm #Causes
Anemia - Hemolysis Diagnostic Algorithm Autoimmune hemolytic anemia Microangiopathic hemolytic anemia Probable thalassemia Dr. Eric Strong @DrEricStrong - Strong Medicine
Anemia - Hemolysis ... Algorithm Autoimmune hemolytic ... anemia Microangiopathic ... hemolytic anemia ... EricsMedicalLectures/ #Hemolysis
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... of anemia and hemolysis ... Immune-mediated Hemolysis ... • Autoimmune Hemolytic ... Macroangiopathic, Microangiopathic
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
LDH - Assess for hemolysis ... for thrombotic microangiopathy ... infections are common causes
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
fragmentation hemolysis ... toxin-mediated hemolytic-uremic ... Drug-induced thrombotic microangiopathy ... • Mechanical hemolysis ... macroangiopathic hemolytic
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
LDH - Assess for hemolysis ... for thrombotic microangiopathy ... infections are common causes
Hemolysis Classification - Intrinsic and Extrinsic Causes Commentary: Another way to think of immune hemolysis would be
Hemolysis Classification ... and Extrinsic Causes ... think of immune hemolysis ... autoimmune (most of the causes ... Differential #Diagnosis #Causes
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