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Hemolytic Anemia - Hemolysis Diagnostic Workup

Infographic by: Howard Ong

#Hemolysis #Hemolytic #Anemia #Algorithm #MAHA #TTP #Diagnosis #Workup
Hemolytic Anemia ... - Hemolysis Diagnostic ... #Hemolytic #Anemia ... Algorithm #MAHA #TTP ... Diagnosis #Workup #Hematology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Anemias (AIHAs) ... Anemias (AHAs) ... Macroangiopathic, Microangiopathic ... Diagnosis #Algorithm #hematology
Anemia - Hemolysis Diagnostic Algorithm
Autoimmune hemolytic anemia
Microangiopathic hemolytic anemia
Probable thalassemia

Dr. Eric Strong @DrEricStrong - Strong Medicine
Anemia - Hemolysis ... anemia Microangiopathic ... hemolytic anemia ... #Anemia #Algorithm ... #hematology #diagnosis
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
microangiopathies (TMA) - TTP ... Drug-induced thrombotic microangiopathy ... anemia" • HELLP ... differential #diagnosis #hematology ... #hemolysis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Mechanical Trauma (Microangiopathic ... hemolytic anemia ... thrombocytopenic purpura (TTP ... differential #diagnosis #hematology ... #anemia
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Schistocytes: Microangiopathic ... hemolytic anemia ... DIC, TTP, HUS) ... Microspherocytes: Autoimmune hemolytic ... Smear #Analysis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... → Sickle Cell anemia ... Schistocytes DAT(-) → Microangiopathic ... hemolytic anemia ... (TTP, HUS, DIC,
Causes of Hemolytic Anemia - Differential Diagnosis
Inherited
 • Membrane
 • Internal
    - Hemoglobin
Causes of Hemolytic ... Anemia - Differential ... Environment - Microangiopathic ... #Anemia #Differential ... Diagnosis #Causes #hematology
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
hemolytic anemia ... Microangiopathic ... hemolytic anemia ... #hemolytic #anemia ... #Hematology #Pathology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... Bleed • Hemolysis ... Fragments • Microangiopathic ... Hemolytic Anemias ... Algorithm #Causes #Hematology