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rheumatology differential management signs dermatology sle syndrome algorithm classification erythematosus oncology primary sjogrens systemic aortitis arterial arteritis arthritis ascorbicacid biliary
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Hypersensitivity vasculitis ... gangrenosum • IBD • RA ... Antiphospholipid-antibody syndrome • Vasculitis ... lesions • Discoid lupus ... #differential #diagnosis
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
- Differential Diagnosis ... ANCA associated vasculitis ... Rheumatoid Arthritis (RA ... ), Systemic lupus ... #rheumatology
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
blood vessels (vasculitis ... inflammation tends to cause ... #pathophysiology ... #signs #symptoms ... #diagnosis #ExtraArticular
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... inflammation on skin ... Livedo Reticularis, Vasculitis ... #diagnosis #signs ... #symptoms #complications
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... inflammation Others: • Lupus ... such as systemic lupus ... Presentation - Systemic Symptoms ... #rheumatology #
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Sjögrens (15%) Skin ... Butterfly rash, Vasculitis ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
rheumatoid arthritis (RA ... ) or systemic lupus ... Xeroderma (Dry skin ... Sjogrens #Syndrome #Pathophysiology ... #Diagnosis #Signs
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... - Differential Diagnosis ... (lupus, RA, Sjogren's ... cryoglobulins • Skin ... #Algorithm #Causes
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... - Purpura - Skin ... Cryoglobulins Cause ... - 10% SLE or RA ... (e.g. systemic lupus
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Post-strep GN, Lupus ... Glomerulonephritis #Vasculitis ... #differential #diagnosis
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