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Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
vasculitis - Diagnosis ... vasculitis Clinical ... manifestations - Skin ... #Vasculitis #Rheumatology ... #Diagnosis #Management
Diagnosis of Cryoglobulinemia Vasculitis

1) Presence of cryoglobulin 
Circulating immunoglobulins that precipitate with cold temperature and dissolve
Diagnosis of Cryoglobulinemia ... Vasculitis 1 ... 3 types 2) Vasculitis ... #Vasculitis #Diagnosis ... #Rheumatology #
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
vasculitis Associated ... • Absence of skin ... min/1.73 m2 at diagnosis ... • Dialysis at diagnosis ... #Rheumatology #
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
the Skin - Differential ... Diagnosis Framework ... Urticarial/LCV) - Cryoglobulinemic ... #skin #dermatology ... differential #diagnosis
Cryoglobulinemia Vasculitis
#rheumatology #diagnosis #signs
Cryoglobulinemia ... Vasculitis #rheumatology ... #diagnosis #signs
Small Vessel Vasculitides
 • Granulomatosis with polyangiitis - Granulomatous manifestations (e.g., nasal crusting, destructive sinusitis, pulmonary
Small Vessel Vasculitides ... involvement • Cryoglobulinemic ... vasculitis - Associated ... in absence of skin ... #diagnosis
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... reticularis & skin ... Labs/Diagnosis: ... Cryoglobulins #diagnosis ... classification #rheumatology
Skin Ulcers by Etiology - Differential Diagnosis Algorithm
Physical:
 • Trauma
 • Pressure
 • Radiation
Vascular:
 • Arterial
Skin Ulcers by Etiology ... - Differential Diagnosis ... insufficiency • Vasculitis ... Thalessemia • Cryoglobulinemia ... #Differential #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... ANCA +MPO) • Cryoglobulinemic ... Vasculitis - Skin ... Presentation - Systemic Symptoms ... #rheumatology #
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... purple, hemorrhagic skin ... /HSP • Cryoglobulinemia ... #Differential #Diagnosis ... #hematology #rheumatology