115 results
Cutaneous Manifestations of Monoclonal Gammopathy
 • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Manifestations of Monoclonal ... Deposits: Systemic amyloidosis ... , Nodular amyloidosis ... NaderYatim #monoclonal
Amyloidosis Diagnosis
1) Patient presentation
 • Cardiac-specific signs of amyloidosis: Diastolic heart failure, Heart failure with preserved
Amyloidosis Diagnosis ... Noncardiac signs of amyloidosis ... and diarrhea, Monoclonal ... noncardiac signs: monoclonal ... immunofixation: Presence of monoclonal
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Multiple Myeloma and Monoclonal ... if this is is monoclonal ... deposition disease, and amyloidosis ... Other causes of a monoclonal ... diseases, CML, amyloidosis
Macroglossia in Light-Chain Amyloidosis- Physical examination revealed macroglossia, with indentations from the teeth (Panel A)...A biopsy
in Light-Chain Amyloidosis ... light-chain (AL) amyloidosis ... , monoclonal light ... AL amyloidosis is ... #macroglossia #amyloidosis
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Monoclonal Gammopathy ... abnormal intact monoclonal ... : • Serum IgM monoclonal ... multiple myeloma, AL amyloidosis ... myeloma and AL amyloidosis
Amyloidosis - Summary
Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
Amyloidosis - Summary ... Primary amyloid amyloidosis ... • Senile amyloidosis ... Amyloidosis ... AL Protein: Monoclonal
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Can Feature A Monoclonal ... Fibrillar deposits: • Amyloidosis ... and monoclonal ... CVS+joints) • Amyloidosis ... Paraproteinemias #Hematology #Monoclonal
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
it represents a monoclonal ... Causes of Monoclonal ... macroglobulinemia • Amyloidosis ... endocrinopathy, monoclonal ... (light chain) amyloidosis
Therapy for AL Amyloidosis 2019 
 - Antibodies (Plasma cells) 
 - Proteasome Inhibitors 
 -
Therapy for AL Amyloidosis ... Amyloid_Planet #Amyloidosis ... #ALAmyloidosis
Nomenclature of Monoclonal Antibodies (-mab)

- Dr. Axel Grothey
@agrothey

#Nomenclature #Monoclonal #Antibodies #Mab #Antibody #Naming
Nomenclature of Monoclonal ... #Nomenclature #Monoclonal