26 results
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Myositis and Myopathies ... Anti-Jo, +Anti-Mi2 Dermatomyositis ... muscle weakness, rash ... Inclusion Body Myositis ... #differential #diagnosis
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... Dermatomyositis ... can present with rash ... /full triad at diagnosis ... #diagnosis #rheumatology
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Creatine Kinase - Causes ... of Elevated CK ... Inflammatory myopathy: dermatomyositis ... Inclusion body myositis ... #differential #diagnosis
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... • Blood tests: Elevated ... or GGT, without elevated ... #dermatology #diagnosis
Causes of Rhabdomyolysis - Differential Diagnosis
 • Drugs & Toxins (Statins, alcohol, cocaine)
 • Direct Muscle
Causes of Rhabdomyolysis ... - Differential Diagnosis ... Damage (Trauma/crush ... Muscle Disease (myositis ... #Causes
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Tetanus, Transverse Myelitis ... , Polymyositis/dermatomyositis ... Neuromuscular #Weakness #Causes ... #differential #diagnosis
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
Causes of Peripheral ... - Differential Diagnosis ... muscle involvement, elevated ... Statin Toxicity • Dermatomyositis ... #Algorithm #Causes
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis ... clinical findings Elevated ... -> Heliotrope Rash ... flexors affected #Dermatomyositis ... Polymyositis #PM #Diagnosis
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
bouts of HTN Diagnostic ... CSF pleocytosis, elevated ... Diagnosis: • ... - Elevated IgG ... • Infectious causes
Anaplasma Infection - Anaplasma phagocytophilum
Pathophysiology: 
 • Obligate, intracellular bacteria
 • Transmitted via blacklegged tick —
shaking chills • Rash ... is rare (< 10% cases ... ), cough (30% cases ... thrombocytopenia • Elevated ... Anaplasma #Infection #diagnosis