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diagnosis rheumatology management erythematosus vasculitis classification dermatomyositis differential druginduced manifestations photo signs skin syndrome systemic activation antimda5 antimda5dm antinxp2 antinxp2dm
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Rare (SSA+ for cutaneous ... Discontinuation of causal ... rare), Topics for cutaneous-DIL ... 40, F:M 9:1 • Clinical
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... response -> Subacute cutaneous ... lupus: scaly annular ... hair follicles -> causes ... #SLE #Mucocutaneous
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... the context of cutaneous ... disease (10%) : SLE ... Vasculitis #dermpath #dermatology ... lesions #diagnosis #clinical
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... 40, F:M 9:1 • Clinical ... Manifestations: Malar rash ... , oral ulcers, Lupus ... Positive in 60-80% of cases
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... scarring • Subacute cutaneous ... lymphoproliferative syndrome Clinical ... inflammation Cutaneous
Subacute Cutaneous Lupus erythematosus (SCLE): Erythematous, warm, plaques in light exposed distribution (also on patient's neck),
Subacute Cutaneous ... Lupus erythematosus ... UCSD Catalog of Clinical ... Images #Clinical ... #Dermatology #SkinRash
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Syndrome: • Clinical ... Henoch-Schönlein purpura) • Cutaneous ... (e.g. systemic lupus
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
- Rash: multiple ... Most common extra cutaneous ... Causes: - Idiopathic ... ’s syndrome - Lupus ... Syndrome #diagnosis #dermatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Systemic lupus ... fever syndromes Clinical ... Fever is the main clinical ... SJIA], systemic lupus ... erythematosus [SLE
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
DERMATOMYOSITIS Cutaneous ... (blue-purple) rash ... • Erythematous rash ... auricular papules Clinical ... #rheumatology #dermatology
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