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diagnosis differential dermatology rheumatology vasculitis dermatomyositis management pathophysiology illness leptospirosis lupus manifestations neurology phases sle syphilis acute algorithm allergy anaphylaxis
Stages of Syphilis Early Primary: • Painless chancre • Regional lymphadenopathy Early Secondary: • Fever, malaise • Rash
Fever, malaise • Rash ... testing • No symptoms ... lesions in bone, skin ... Syphilis #Stages #symptoms ... #signs #diagnosis
Secondary Syphilis Rash Secondary syphilis is the most contagious of all the stages of this disease, and
Secondary Syphilis Rash ... Skin rash and malaise ... The signs and symptoms ... ▪ “Rash” (75% ... resembling rashes caused
Anaplasma Infection - Anaplasma phagocytophilum Pathophysiology: • Obligate, intracellular bacteria • Transmitted via blacklegged tick —
within morulae Signs ... and symptoms: ... shaking chills • Rash ... is rare (< 10% cases ... ), cough (30% cases
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... plugging -> Discoid Rash ... inflammation on skin ... Malar (butterfly) Rash ... pathophysiology #diagnosis #signs
Kawasaki Disease: Clinical Findings Diagnostic Criteria - Fever and 4/5 of the following: • Conjunctivitis • Polymorphous
• Polymorphous rash ... hands & feet Signs ... - Generalized Skin ... Rash #Kawasaki ... Pathophysiology #Signs
SKIN RASHES Skin rashes can occur from a variety of factors, including infections, heat, allergens, immune
SKIN RASHES ... Skin rashes ... fever and systemic signs ... rashes into these classes ... petechiae; #purpura; #rash
Manifestations of Anaphylaxis by Body System Dermatologic/mucosal - Eyes: periorbital swelling/erythema, injected conjunctiva, tears - Oral mucosa:
tongue and lips - Skin ... : urticarial rash ... , morbilliform rash ... Diagnosis #Allergy #Signs ... #Symptoms #Anaphylaxis
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 ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign
Extrapulmonary manifestations of COVID-19 • Neurologic: Headaches, Dizziness, Encephalopathy, Guillain-Barré, Ageusia, Myalgia, Anosmia, Stroke • Renal:
Gastrointestinal: Diarrhea, Nausea ... , Erythematous rash ... Extrapulmonary #Diagnosis #Signs ... #Symptoms #SARSCOV2
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... erythematosus #signs ... #symptoms #diagnosis
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