10 results
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... pathogens Bacterial ... activation -> Complement ... #pathophysiology
Gonorrhea: Pathophysiology

 - Neonatal Transmission -> Direct contact of patient mucosa with mother's infected mucosa while
Gonorrhea: Pathophysiology ... eradication of pathogen ... Pathogen cleared ... antibodies and causes ... activation of complement
Humoral Immunity - Pathogenesis and Clinical Findings
Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
produced from pathogens ... (bacteria, viruses ... Opsonization: Abs coat pathogens ... Neutralization: Abs bind to pathogen ... Humoral #Immunity #pathophysiology
Causes of Sore Throat / Rhinorrhea - Differential Diagnosis Algorithm
Common viral pathogens: Rhinovirus, Coronavirus, Influenza virus,
Causes of Sore Throat ... Differential Diagnosis Algorithm ... Common viral pathogens ... pathogen: Group ... #causes #primarycare
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures
 - Did they receive antibiotics prior
therapy - Number one cause ... have a fastidious bacteria ... this be a non-bacterial ... pathogen? ... Diagnosis #Management #Algorithm
Septic Arthritis: Pathogenesis and clinical findings
Notes:
- Septic Arthritis is typically monoarticular & the knee is involved
involved in >50% of cases ... Microbiology: - Bacterial ... S.A. can also be caused ... non-gonnococcal pathogen ... SepticArthritis #pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... staining): • Low Complement ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
• Most common cause ... Lung Abscess Pathophysiology ... Lung Abscess Pathogens ... : • Aerobic Bacteria ... #differential #causes
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm
Structural Defect - Asplenia/HypospIenism
 • Bacteremia/Septic
Causes of Fever ... HypospIenism • Bacteremia ... • Encapsulated Bacteria ... Periodontal Disease Complement ... #Causes #Hematology
SEPSIS AND SEPTIC SHOCK

DEFINITION AND PATHOPHYSIOLOGY
 • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
DEFINITION AND PATHOPHYSIOLOGY ... • Pathophysiology ... NETs), cytokines, complement ... • Pathogens: ... Gram-positive/-negative bacteria