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diagnosis rheumatology management erythematosus autoantibodies activation ana antinuclear associations cerebritis classification cns comparison differential druginduced eularacr immune inflammatory iris macrophage
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... Clinical Domains ... pericarditis • Hematologic ... #SLE #Systemic
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ... Anti-cardiolipin (aCl ... LAC) • Sjogren Syndrome ... • Scleroderma (Systemic ... #associations #table
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... (SLE) Clinical ... Demyelinating Syndrome ... #SLE #CNS #neurology ... #rheumatology #
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic ... is clinically suspected ... overlap syndromes ... #diagnosis #rheumatology ... #table #ANA
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... thiazidic, PPI, ACE ... months to years) Systemic ... 40, F:M 9:1 • Clinical ... #table #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lupus erythematosus ... [SLE], AOSD) • ... Histopathologic criteria ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... reconstituted immune system ... specific diagnostic criteria ... fevers • MAC/NTM ... organizing PNA • Mycobacterium
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