3321 results
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
dysmotility • MCTD (SLE ... • Specific for SLE ... dose steroid+ mycophenolate ... Erythematosus #SLE ... #rheumatology #management
Immunosuppressive Medications in Systemic Lupus Erythematosus (SLE)
 - MTX (oral, subcutaneous)
 - AZA (oral) 
 -
Erythematosus (SLE ... voclosporin) - Mycophenolate ... (oral; mycophenolate ... x 6–7 times) #SLE
Mycophenolate Mofetil versus Cyclophosphamide for Induction Treatment of Lupus Nephritis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678035/

Mycophenolate versus Azathioprine as Maintenance Therapy
Mycophenolate Mofetil ... PMC2678035/ Mycophenolate ... NEJMoa1014460 #ALMS #Mycophenolate
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... Diagnosis and Management ... are evocative of SLE ... Usual therapeutic management ... Erythematosus #Diagnosis #Management
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
Cyclophosphamide, Mycophenolate
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... Erythematosus (SLE ... are evocative of SLE ... Usual therapeutic management ... rheumatology #diagnosis #management
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... Association with both SLE ... Anti-Ribo-P 5-15% If SLE ... higly specific for SLE ... patients with typical SLE
Bronchiectasis: diagnosis and management 

Causes of localized -> diffuse bronchiectasis
Foreign body, Bronchial stenosis (tumor, .. ),
diagnosis and management ... RA, Sjögren, SLE ... Bronchiectasis #diagnosis #management
Clinical Manifestations of Systemic Lupus Erythematosus (SLE)

#Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Erythematosus (SLE ... Erythematosus #SLE
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Spondyloarthropathies, SLE ... retinal exudates) - SLE ... nodules - RA, SLE ... disease - RA - SLE ... • Seizures - SLE