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Immunosuppressive Medications in Systemic Lupus Erythematosus (SLE) - MTX (oral, subcutaneous) - AZA (oral) -
Erythematosus (SLE ... voclosporin) - Mycophenolate ... (oral; mycophenolate ... x 6–7 times) #SLE
Mycophenolate Mofetil versus Cyclophosphamide for Induction Treatment of Lupus Nephritis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678035/ Mycophenolate versus Azathioprine as Maintenance Therapy
Mycophenolate Mofetil ... PMC2678035/ Mycophenolate ... NEJMoa1014460 #ALMS #Mycophenolate
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
manifestations • Neonatal SLE ... dysmotility • MCTD (SLE ... • Specific for SLE ... dose steroid+ mycophenolate ... Erythematosus #SLE
Immune Reactions and Immunosuppressant Drugs Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2 Muromonab-CD3 - Monoclonal antibody Calcineurin
Cyclophosphamide, Mycophenolate
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... Anti-Ribo-P 5-15% If SLE ... Associated with SLE-SSc-AlM ... higly specific for SLE ... patients with typical SLE
Clinical Manifestations of Systemic Lupus Erythematosus (SLE) #Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Erythematosus (SLE ... Erythematosus #SLE
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Spondyloarthropathies, SLE ... retinal exudates) - SLE ... nodules - RA, SLE ... disease - RA - SLE ... • Seizures - SLE
Common causes of post-Transplant Diarrhea • Bacterial: Clostridium difficile, Campylobacter spp., Salmonella spp., Bacterial overgrowth, Aeromonus
IS medications: Mycophenolate
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Levels - C3, C4 • SLE ... • Infection eg SBE
Flail Chest on Physical Exam Anterior flail chest post MVA, see seatbelt sign as another clue Neville @docvlok #Flail
chest post MVA, see ... PhysicalExam #clinical #video
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