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Algorithm for the Evaluation and Management of Transfusion Reactions

This algorithm was developed by Dr. Eric Madden,
of Transfusion ... Reactions This ... #Transfusion #Reactions ... #Algorithm #Diagnosis ... #Management #Hematology
Transfusion Reactions - Summary Cheatsheet
 • Hemolytic Reaction
 • Febrile Reactions
 • Transfusion Related Acute Lung
Transfusion Reactions ... Cheatsheet • Hemolytic Reaction ... • Febrile Reactions ... #Reactions #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Reaction (FNHTR ... Reaction (AHTR) ... Reaction (DHTR) ... #diagnosis #management ... #hematology #reactions
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Reactions Immune ... Reaction (FNHTR ... Reaction (AHTR) ... #diagnosis #management ... #hematology #reactions
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... reaction, Paroxysmal ... #hematology #anemia
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
suspect underlying hematologic ... disorders • Diagnosis ... #HES #Hematology ... #eosinophils #diagnosis ... #management #algorithm
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Kawasaki, Nephrotic syndrome ... , POEMS • Reaction ... Exercise, Allergic reactions ... #Differential #Diagnosis
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
TRALI vs TACO - Transfusion ... Reactions TRALI ... plasma volume transfusion ... #Reactions #hematology ... #diagnosis #comparison
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... AIHA, Cold AIHA, Transfusion ... reactions, Drug-associated ... , PCH, Evans Syndrome ... #hematology
Consensus Indications for Irradiated RBC Transfusions:

Cellular blood components are irradiated for the prevention of TA-GVHD. Transfused
Irradiated RBC Transfusions ... disorders (DiGeorge Syndrome ... Intrauterine and neonatal transfusions ... #Indications #Hematology ... #BloodBank #Management