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differential algorithm acute hematuria hyponatremia workup blood glomerulonephritis kidneyinjury management syndromes urology amyloid amyloidosis associated atlas classification comparison diseases gn
Nephritic vs Nephrotic Syndrome Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes. Step
hematuria and/or proteinuria ... /nephritic syndromes ... casts or dysmorphic ... RBCs in urine)? ... #Diagnosis
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
Nephrotic Syndromes ... RBC casts in urine ... severe cases ... #Nephrotic #Syndromes ... #Nephrology #Diagnosis
Algorithmic Approach to Acute Interstitial Nephritis When to suspect AIN? (not sensitive) • AKI, AKD, rapidly progressive
Acute Interstitial Nephritis ... casts, eosinophiluria ... , granular casts ... #Interstitial #Nephritis ... #nephrology #diagnosis
Urine Microscopy - Casts Acellular Casts • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy ... suggestive of nephrotic ... • RBC Casts - ... #Urine #Microscopy ... #nephrology #interpretation
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... • Fanconi's syndrome ... • Drugs Glomerular ... sediment - WBC/ ... RBC casts
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
- Differential Diagnosis ... hematuria syndrome ... casts → Diagnostic ... - Proteinuria ... #nephrology #renal
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
blood cells on urine ... casts) - Isolated ... • Hereditary nephritis ... and >3.5g/day (nephrotic ... range) proteinuria
Urinary Casts and Disease Associations Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... heme-granular casts ... tubulointerstitial nephritis ... Fatty - Nephrotic ... #Diagnosis #Nephrology
Atlas of Urine Microscopy Findings • Epithelial cells - Normal • Renal tubular cells - Acute
Atlas of Urine Microscopy ... • Red cell casts ... • White cell casts ... • Hyaline casts ... #nephrology #casts
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
GN • Active Urine ... , RBC casts, +/- ... proteinuria) ... glomerulopathy, radiation nephritis ... #diagnosis #renal
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