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differential causes management chronic cll extravascular hemolysis lymphocytic workup agglutinin anemias aplastic classification cold disease hemeonc hodgkins index lymphoma mcv
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Diagnosis Algorithm ... elliptocytosis - RBC ... circulation - ... anemia • ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... • Intrinsic RBC ... G6PD deficiency) ... #Hemolytic #Intravascular ... #hematology #anemia
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
of anemia and hemolysis ... : • Autoimmune ... (AIHAs) • Alloimmune ... #Diagnosis #Algorithm ... #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
to Anemia - Differential ... Sideroblastic anemia ... ACD, Aplastic anemia ... MatthewHoMD #Anemia ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... elliptocytosis, autoimmune ... #Anemia #Differential ... #Diagnosis #Algorithm ... #workup #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Index < 2: • Anemia ... : Autoimmune, Microangiopathic ... hemolytic anemia ... Production #Index #hematology ... #diagnosis #calculation
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Chronic Myelogenous Leukemia ... effect following treatment ... malignancy • Iron deficiency ... anemia #Thrombocytosis ... #Hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... cytopenias (ITP, AIHA ... marrow failure with anemia ... AIHA, PRCA) • Treatment ... #oncology #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... • Symptoms of anemia ... Diagnosis: • hemolytic ... anemia • Cold ... #anemia #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... virus (EBV) • Leukemia ... Treatment: ... #oncology #hematology ... #diagnosis #management
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