38 results
diagnosis differential treatment lupus oncology sle algorithm anemia classification disease erythematosus intravascular syndrome extravascular hemolysis hemolytic hemophagocytic hlh lymphohistiocytosis signs
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
↑ LDH • Anti-RBC ... 2) LOOK FOR a cause ... → Systematic screening ... Anemia #diagnosis #management ... #treatment #rheumatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Reactive: - Systemic ... Inflammatory • Systemic ... (Pancytopenia, WBC ... #Hematology #Oncology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis ... Scleroderma) Multi-system ... autoimmune disease ... pericarditis • Hepatic: PBC ... Scleroderma #SSc #rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Atypical HUS, autoimmune ... glomerulonephritis (>90%) S - Systemic ... #differential #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
on the left Myeloblast ... Corticosteroid use • Autoimmune ... Even with normal WBC ... 21% had normal WBC ... #CBC #hematology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... (vasculitis / autoimmune ... Lymphomas - Systemic ... Differential #Diagnosis #Causes ... #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Cold AIHA • Alloimmune ... elliptocytosis - RBC ... Diagnosis #Algorithm #Causes ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... idiopathic) - Autoimmune ... • Intrinsic RBC ... Extravascular #Causes ... differential #diagnosis #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Diagnosis and Management ... Positive in 60-80% of cases ... #SLE #lupus #Systemic ... #Summary #rheumatology
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
ophtho referral • Systemic ... Neuro disease: • Systemic ... by case) • Surgery ... Syndrome #Treatment #management ... #pharmacology #rheumatology
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