16 results
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Reactive: - Systemic ... (Pancytopenia, WBC ... Lymphocytic Leukemia (CBC ... #Hematology #Oncology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Diagnosis Algorithm Signs ... Hemolysis: • Autoimmune ... • Extrinsic RBC ... • Intrinsic RBC ... Diagnosis #Algorithm #hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
↑ LDH • Anti-RBC ... • Blood smear: Differential ... 2) LOOK FOR a cause ... → Systematic screening ... #treatment #rheumatology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
on the left Myeloblast ... Even with normal WBC ... relative to both WBC ... 21% had normal WBC ... #CBC #hematology
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
autoimmune disease ... skin thickening Signs ... pericarditis • Hepatic: PBC ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... Intravascular Hemolysis - Differential ... Cold AIHA • Alloimmune ... elliptocytosis - RBC ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... • Intrinsic RBC ... Extravascular #Causes ... #differential # ... diagnosis #hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... count cause hyperviscosity ... • Lab values: WBC ... >100k, + lab signs ... #hematology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Pain - Arthritis Differential ... , erythema and WBC ... noninflammatory Signs ... weeks) Can Be Caused ... Diagnosis #MSK #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... disease • Non-autoimmune ... rheumatologic diseases ... titers > 1:80 • CBC ... Erythematosus #Diagnosis #Rheumatology