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diagnosis anemia oncology algorithm causes extravascular hemolytic intravascular agglutinin atlas bloodcell calculation cold hemeonc hodgkins index injury leukemia liver lupus
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(AIHA) "Warm" ( ... ) (e.g. lupus, CLL ... (AIHA)"Cold" (usually ... • Intrinsic RBC ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Immune-Mediated • Warm AIHA ... • Cold AIHA ... • Drug-induced AIHA ... elliptocytosis - RBC ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... 2) External (RBC ... : Warm AIHA, Cold ... AIHA, Transfusion ... Diagnosis #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Bite Cell RBC: G6PD ... hemolytic anemia ... Target Cell RBC ... hemolytic anemia ... #diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... hemolytic anemia ... , Intrinsic RBC ... Production #Index #hematology ... #anemia #differential
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Vmphocytosis on routine CBC ... cytopenias (ITP, AIHA ... AIHA, PRCA) • Treatment ... Leukemia #oncology #hematology ... hemeonc #diagnosis #management
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune hepatitis ... , PBC, PSC, IgG4 ... • Bilirubin: RBC ... • LDH: Heart, RBC ... diagnosis #algorithm #hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... been reported (eg AIH-PBC ... If suspected, AIH ... #Hepatitis #AIH ... #Hepatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... Blood smear - RBC ... pts) Differential ... #hemolytic #anemia ... #hematology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... Noninfectious hepatitis ... : • AIHA 10% • ... titers > 1:80 • CBC ... with Lupus: • Chronic
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