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diagnosis differential causes oncology workup management hemolytic rheumatology arthritis chronic disease extravascular hemolysis intravascular leukemia lymphocytic macrocytic testing agglutinin atlas
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Pelger-Huet, Macrocytic anemia ... • Lymphoid (CLL ... - B-cell ... bcr-able (+) ↑ WBC ... #hematology #Markers
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... lymphoproliferative disorders ... • Neutropenia, anemia ... microglobulin Treatment ... workup #oncology #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... Unstable hemoglobin disorders ... differential #diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Differential Diagnosis Algorithm ... Artifact (redo CBC ... • Rheumatic disorders ... effect following treatment ... Iron deficiency anemia
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... Anemia is described ... leads to anemia ... peripheral blood cell ... Red cell distribution
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... Vmphocytosis on routine CBC ... 5) Symptoms of anemia ... Transformation to large cell ... marrow failure with anemia
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... corpuscular (cell ... Red cell distribution ... for degree of anemia ... thecurbsiders podcast #Anemia
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... Left Shift: • Cell ... precursors" • Stab cell ... on the left Myeloblast ... #CBC #hematology
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
: • Squamous cell ... carcinoma • Basal cell ... fungoides (cutaneous T-cell ... : • Sickle Cell ... Anemia • Thalessemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... membrane disorder ... ARUPLabs #Hemolytic #Anemia ... #workup #hematology
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