14 results
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
RBC casts in urine ... but in severe cases ... #Classification ... #Proteinuria #Nephrology ... #Diagnosis
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
hematuria and/or proteinuria ... hematuria (RBC casts ... #Syndrome #Comparison ... #Algorithm #Nephrology ... #Diagnosis
Atlas of Urine Microscopy Findings
 • Epithelial cells - Normal
 • Renal tubular cells - Acute
Atlas of Urine Microscopy ... • Red cell casts ... • White cell casts ... • Hyaline casts ... #nephrology #casts
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
hematuria: - RBC casts ... - Proteinuria ... #Diagnosis #causes ... #urology #nephrology ... #renal #urine #
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... • Drugs Glomerular ... sediment - WBC/RBC casts ... polyangiitis (GPA) / microscopic ... #Nephrology #Differential
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
repeat testing • Acute ... , RBC casts, dysmorphic ... → Refer to Nephrology ... for renal biopsy ... cystoscopy • Refer to Nephrology
Acute Kidney Injury - Differential Diagnosis Framework
PRERENAL:
 - Intrarenal vasoconstriction-hemodynamically mediated
 - Systemic vasodilation
 - Volume
INTRINSIC: - Glomerular ... white blood cell casts ... tubular cell casts ... or pigmented casts ... : Avoiding nephrotoxic
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... heme-granular casts ... edgarvlermamd - Nephrology ... Microscopy #Diagnosis ... #Nephrology
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy ... suggestive of nephrotic ... #Urine #Microscopy ... #nephrology #interpretation ... #diagnosis
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
cell/white cell casts ... Nephrocalcinosis causes ... #diagnosis #glomerular ... #proteinuria #nephrotic ... #syndrome #nephrology