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Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... -> AML: Blast crises ... Neutrophils • Immature/Myeloblasts ... • Tumor lysis syndrome ... Hematology #Oncology #Diagnosis
Hyperviscosity Syndrome - Causes and Treatment - Waldenstrom macroglobulinemia (most common) / Plasmapheresis - Multiple
Hyperviscosity Syndrome ... - Causes and Treatment ... Hydroxyurea - Leukemia ... hyperleukocytosis (AML ... #Diagnosis #Treatment
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
- Differential Diagnosis ... (AML) • Chronic ... Renal • Chronic ... #Differential #Diagnosis ... endocrinology #causes
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... - Differential Diagnosis ... Myelodysplastic syndrome ... myeloid leukemia ... (CML) - Dr.
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... microglobulin Treatment ... • Sezary syndrome ... #CLL #Chronic ... #diagnosis #workup
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... - Differential Diagnosis ... Primary: - CML ... Hypereosinophilic Syndrome ... - Chronic Eosinophilic
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... - Differential Diagnosis ... Myelogenous Leukemia ... : • Acute or Chronic ... effect following treatment
Workup for Hypophosphatemia - Differential Diagnosis Framework Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia Measure Urine Fractional Excretion
Workup for Hypophosphatemia ... - Differential Diagnosis ... paraproteinemia, acute leukemia ... Malabsorption, Chronic ... #Framework #Workup
Eosinophilia - Differential Diagnosis Algorithm Idiopathic Eosinophilia Primary Eosinophilia: • Primary hypereosinophilic syndrome • Eosinophilic Leukemia • MPN/MDS
- Differential Diagnosis ... • Eosinophilic Leukemia ... ), Heme malig (AML ... insufficiency, Chronic ... #Differential #Diagnosis
Causes of Anterior Uveitis - Differential Diagnosis Anterior Uveitis - 90% of cases of Uveitis • Inflammation
Causes of Anterior ... - Differential Diagnosis ... Immunocompromised-CMV • Chronic ... : Malignancy - Leukemia ... #Causes #ophthalmology
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