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differential hematology management oncology algorithm syndrome chronic classification dermatology disorders fever fuo hiv hodgkins lymphadenopathy lymphoproliferative neurology rheumatology workup abdominal
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• Cytopenia -> BM ... -> AML: Blast crises ... Neutrophils • Immature/Myeloblasts ... Age: 50-60 • Auer ... #Oncology #Diagnosis
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
She was diagnosed ... promyelocytic leukemia ... a bone marrow (BM ... hospitalization and treatment ... acute myeloid leukemia
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 Hyperviscosity Syndrome - Causes and Treatment - Waldenstrom macroglobulinemia (most common) / Plasmapheresis - Multiple
Hyperviscosity Syndrome - Causes ... and Treatment ... hyperleukocytosis (AML ... - MH/CCF/CWRU EM ... #Differential #Diagnosis
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... - Differential Diagnosis ... Infectious • EBV ... Non-Hodgkin's Lymphoma ... #Algorithm #Causes
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
- Differential Diagnosis ... Ovarian - Leukemia ... /Lymphoma: NHL, ... CML • Miscellaneous ... #Algorithm #causes
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
the non-Hodgkin lymphoma ... phenomenon CLL Diagnosis ... microglobulin Treatment ... Transform to DLBCL, PML ... #diagnosis #workup
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
- Differential Diagnosis ... Bacterial • Viral (EBV ... Malignant • Lymphoma ... • Leukemia ... #Differential #Diagnosis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... Responsive to Treatment ... Treated Like Acute Leukemias ... growth, response to treatment ... relapse - Amy
Differential Diagnosis for Generalized Lymphadenopathy Viral • HIV • EBV • CMV • HBV • Dengue • Rubella
Differential Diagnosis ... Viral • HIV • EBV ... Malignancy • Lymphoma ... • Leukemia • ... #Causes #Algorithm
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Immunosuppression (e.g., HIV), EBV ... involved) • No leukemic ... Differential Diagnosis ... , ALL) • Solid ... comparison #oncology #diagnosis
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