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Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
- Differential Diagnosis ... deficiency) • Infection ... Chronic Myeloid Leukemia ... #Differential #Diagnosis ... causes #Platelets #hematology
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
- Differential Diagnosis ... Algorithm Infection ... Chronic myelogenous leukemia ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
- Differential Diagnosis ... History of Bleeding, Infection ... Lymphoblastic Leukemia ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... pain, bleeding, infections ... Neutrophils • Immature/Myeloblasts ... #Hematology #Oncology ... #Diagnosis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential Diagnosis ... Leukemia, Tumour ... Vasculitis • Infection ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
- Differential Diagnosis ... Chronic myeloid leukemia ... Acute myeloid leukemia ... #Differential #Diagnosis ... #causes #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... Cancer: • Leukemia ... deficiency Infections ... #Differential #Diagnosis ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential Diagnosis ... Thrombocytosis): • Acute infection ... Chronic myeloid leukemia ... #Differential #Diagnosis ... #Causes #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - Diagnosis ... 10,000 new cases diagnosed ... risk-stratification • Risks: infection ... transformation to acute leukemia ... Management #treatment #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... weeks without infection ... phenomenon CLL Diagnosis ... #diagnosis #workup ... #oncology #hematology
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