13 results
Gout: Pathogenesis and Clinical Findings
 - Conditions of rapid cell turnover: hemolysis, psoriasis, lymphoproliferative disorders
 -
for excretion in urine ... cascade results in leukocyte ... tophaceous gout #Hyperuricemia ... #Pathophysiology
Hyperuricemia - Differential Diagnosis Algorithm
Primary - Over-production
     • Increased turnover of nucleotides
Primary
Hyperuricemia - ... Differential Diagnosis ... Drug-induced • High purine ... gout #UricAcid #Hyperuricemia ... #Differential #
Hyperuricemia: Pathogenesis and Complications

 - Hypercalcemia (due to diseases like Sarcoidosis and Hyperparathyroidism) -> Accumulation of
Hyperuricemia: Pathogenesis ... -> Release of purine ... uric acid >> Hyperuricemia ... the blood #Hyperuricemia ... #Pathophysiology
Types of Renal Calculi

Calcium oxalate
 - Interstitial apatite plaque, Low urine volume, Increased urinary calcium excretion,
apatite plaque, Low urine ... duct plaque, Low urine ... Uric acid - Hyperuricemia ... - Hyperuricemia ... Renal #stones #differential
Purple Urine Bag Syndrome
Chronic, indwelling catheter + bacteriuria (Providencia, Klebsiella, E.coli*) + alkaline urine
Tryptophan → Indoxyl
Purple Urine Bag ... E.coli*) + alkaline urine ... BrighamChiefs #Purple #Urine ... Syndrome #PUBS #pathophysiology ... clinical #photo #differential
Lower Urinary Tract Infection: Pathogenesis and Clinical Findings

- Predisposing Factors:  Immunocompromised state, diabetes, elderly, female
urethra), stagnant urine ... systems, or stagnant urine ... Tenderness - Urine ... (+) Nitrites, Leukocyte ... UrinaryTractInfection #LUTI #Pathophysiology
Evaluation of Leukocytosis:
The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages.
Include
Leukocytosis: The term 'leukocyte ... cells within the myeloblast ... part automated differential ... precursor cells to leukocytes
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Rhabdomyolysis - Differential ... Dermatomyositis) AKI - Pathophysiology ... hour with goal urine ... Allopurinol for hyperuricemia ... Rhabdomyolysis #Differential
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Rhabdomyolysis - Differential ... Weakness - Dark urine ... Hypercalcemia • Hyperuricemia ... hour with goal urine ... Rhabdomyolysis #Differential
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
peripheral blood leukocytes ... on the left Myeloblast ... Neutrophil (Normal) Differential ... #Bandemia #differential ... CBC #hematology #pathophysiology