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diagnosis hematology management oncology blood product reactions sweet acute algorithm antibiotics apml criteria dermatosis differentiation hantavirus hemophagocytic hlh infant infectiousdiseases
Hantavirus Pathogen: Hantavirus - Rodents are the primary reservoir Transmission: • Shed in the urine, feces, saliva of
• Shed in the urine ... Cardiopulmonary Syndrome ... (HCPS): Febrile ... • Prodrome: fever ... #microbiology #
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... an infant with fever ... >21 days - No leukocytes ... in urine - Procalcitonin ... Pediatrics #Peds #Febrile
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... Neutrophils • Immature/Myeloblasts ... develop leukostasis syndrome ... • Tumor lysis syndrome ... Lymphadenopathy • HSM • Fevers
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis) Major criteria 1. Abrupt onset of tender
Criteria for Sweet Syndrome ... (Acute Febrile ... Fever, temperature ... Excellent response to treatment ... C-reactive protein; leukocyte
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... organ damage • Treatment ... : - If febrile ... Low calcium • Treatment ... diagnosis #management #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Acute febrile ... characterized by fever ... Disorder: - Fever ... Treatment: - Systemic ... #diagnosis #dermatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... Rare: DAH, acute febrile ... Renal Failure Treatment
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... acute or subacute febrile ... following: • Fever ... • Bicytopenia Treatment ... #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Product Types: • Leukocyte ... Mediated: - Febrile ... S/sx: Fever, flank ... pain, dark urine ... proteins on plts, leukocytes
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Mediated: • Febrile ... S/sx: Fever, flank ... pain, dark urine ... proteins on plts, leukocytes ... Sx include: fever
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