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hematology diagnosis oncology differential management algorithm causes aplastic chronic cll lymphocytic mds myelodysplastic platelets apl auer auerrods bandemia blood bloodsmear
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Chronic Myelogenous Leukemia ... effect following treatment ... Iron deficiency anemia ... Algorithm #Causes #Hematology
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Thrombocytosis - ... Reactive: • Anemia ... Chronic Myeloid Leukemia ... BrighamChiefs #Thrombocytosis ... causes #Platelets #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... a.k.a Reactive Thrombocytosis ... malignancies • Anemia ... Chronic myeloid leukemia ... Diagnosis #Causes #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Lymphocytes - T or B lineage ... ALL is of B-cell lineage ... basophilia, and thrombocytosis ... Neutrophils • Immature/Myeloblasts ... - infiltrates (anemia
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Treatment: • Consider ... to MDS or acute leukemia ... diagnosis #management #treatment ... #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... → Refer to hematology ... Consider reactive thrombocytosis ... hemolysis, deficiency anemia ... Rebound effect from treatment
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... transformation to acute leukemia ... only curative treatment ... Diagnosis #Management #treatment ... #hematology #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic Leukemia ... • Most common leukemia ... 5) Symptoms of anemia ... marrow failure with anemia ... #oncology #hematology
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
promyelocytes, anemia ... promyelocytic leukemia ... hospitalization and treatment ... maturation, and mixed lineage ... leukemia.
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 Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... • Most common leukemia ... • Neutropenia, anemia ... microglobulin Treatment ... workup #oncology #hematology
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