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differential anemia hepatology liver workup causes lfts anemias chemistry classification extravascular hepatitis hodgkins injury interpretation intravascular lymphoma macrocytic management microcytic
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... of anemia and hemolysis ... Reticulocytes • Abnormal ... Membrane defects, Enzyme ... #Algorithm #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Intravascular - Hemolysis ... immune-complex hemolytic ... malformations #Hemolysis
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Algorithm Decreased ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... Anemias (MAHA) - Abnormal ... #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... deficiency, Other enzyme ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic ... #hematology #testing
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... , Spiders - Enzyme ... Blood Smear ↑ abnormal ... Urobilinogen #Hemolysis ... #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
value for this enzyme ... hemorrhage and hemolysis ... intravascular hemolysis ... out an immune hemolytic ... the severity of hemolysis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
CA, small cell lung ... Gilbert's syndrome • Hemolysis ... (hemolysis, bleeding ... (hemolysis) • ... #algorithm #hepatology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Normal range 11.5% ... acute blood loss, hemolysis ... #Diagnosis #Workup ... #Hematology #Microcytic
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Source of Liver Enzyme ... (hemolysis, bleeding ... (hemolysis) • ... Gilbert's syndrome • Hemolysis ... liver #chemistry #diagnosis
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... body mass index; FBC ... mellitus; USS, ultrasound ... #Algorithm #Hepatology ... #Liver #Enzymes
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