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hematology differential management oncology anemia apml calcium comparison cppd deposition differentiation disease elevatedmcv erythrocytosis gout increased macrocytic macrocytosis mds myelodysplasia
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Causes of Neutrophilia ... - Increased Neutrophils ... blast cells) #Neutrophilia ... #Increased #Neutrophils ... #Algorithm #Causes
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Algorithm Normal ... Hypersegmented Neutrophils ... #Algorithm #Causes ... #Hematology
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm Relative - Normal RBC Mass / Decreased Plasma Volume
Causes of Polycythemia ... - Normal RBC Mass ... Abnormal Abdominal Ultrasound ... #Algorithm #Causes ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... thrombocytosis • Polycythemia ... effect following treatment ... #Algorithm #Causes ... #Hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Diagnosis Algorithm ... an underlying cause ... else is driving RBC ... , this list is long ... #Algorithm #workup
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... if high risk if WBC ... acute febrile neutrophilic ... sepsis), PE, DAH, CHF ... QD until normal WBC
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
hit mechanism of neutrophil ... without other cause ... : 33% • Treatment ... : Age>60, CKD, CHF ... #diagnosis #comparison
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
Gout - Diagnosis ... Fluid Testing: • WBCs ... 100,000/μL • Neutrophil ... not possible • Ultrasound ... #rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
(hypogranular neutrophils ... Out Secondary Causes ... factors (examples: G-CSF ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Synovial Fluid: • WBCs ... 2000-100,000/μL; neutrophil ... culture used to diagnose ... Acute Pseudogout: Treatment ... Deposition #Disease #Rheumatology
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