16 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... RBC's secondary to platelet ... • Platelet defects ... : Platelet Defects ... #Differential #
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... - Differential ... History: - Prior platelet ... (petechiae, ecchymoses ... #Platelet #Disorders
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... Gplb receptor • Thrombcytopenia ... Von Willebrand Disease ... #disorders #hematology ... #hemepath #differential
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... / Bruising - Differential ... Diagnosis Algorithm Thrombocytopenia ... Sequestration Disordered ... Platelet Function
Causes of Purpura or Easy Bruising in Children

Platelet count reduced, i.e. thrombocytopenia
 - Increased platelet destruction
in Children Platelet ... - Increased platelet ... Hypersplenism - Impaired platelet ... Drug-induced Platelet ... count normal - Platelet
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Rash - Differential ... hemostasis: - Thrombocytopenia ... - Abnormal platelet ... Vasculitis - Collagen disorders ... Algorithm #Causes #dermatology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Von Willebrand Disease ... disorder Clinical ... Laboratory • Normal platelet ... count (mild thrombocytopenia ... #Diagnosis #Hematology
Bleeding manifestations 
Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
individuals with thrombocytopenia ... lowest levels Platelet ... ability to bind platelets ... VWF:RCo/VWF:Ag (differentiate ... #ecchymosis #thrombocytopenia
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Manifestations of DIC: • Petechiae ... • Purpura • ... Findings in DIC: • Platelet ... - Platelet rich ... • Severe Liver Disease
Platelet Disorders - Differential Diagnosis Framework

Qualitative Defects:
 • Adhesion
 • Aggregation
 • Secretion

Quantitative Defects:
 • Production:
Platelet Disorders ... ASanchez_PS #Platelet ... #Disorders #Differential ... #Diagnosis #hematology ... #thrombocytopenia