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causes platelets basophilia basophils chronic classification cll disorders gap globulin lymphocytic markers mds myelodysplasia myelodysplastic protein proteingap secondary syndromes workup
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Differential Diagnosis ... Reactive: • Anemia ... /blood loss (Fe ... Myelofibrosis • Chronic Myeloid ... #Platelets #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
): • Acute infection ... malignancies • Anemia ... MF) • Chronic myeloid ... leukemia (CML) ... #hematology #secondary
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... Diagnosis Algorithm ... → Refer to hematology ... : Acute blood loss ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... Infectious: • Acute ... Iron deficiency anemia ... Diagnosis #Algorithm ... #Causes #Hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Diagnosis Algorithm ... Acute • Myloid ... Pelger-Huet, Macrocytic anemia ... #Disorders #hematology ... #Diagnosis #Algorithm
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Diagnosis Framework ... the total white blood ... Disorders: • Chronic myeloid ... myeloid leukemia ... #hematology #basophils
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
CML (Chronic Myeloid ... (myeloid)↑ • Mature ... Myeloid Leukemia ... #Hematology #Oncology ... #Diagnosis
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
to Anemia - Differential ... Diagnosis Algorithm ... Blood Loss ... Diagnosis #Algorithm ... #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
- Summary Cancer ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... ’s lymphoma or acute ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
, or all three myeloid ... • Hairy Cell Leukemia ... count with differential ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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