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gammopathy hodgkins leukemia lymphoma mgus myelodysplastic workup agglutinin algorithm anemia arthritis basophilia basophils cancer causes chronic classification cll cold complications
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
(MGUS) - Differential ... Diagnosis Neurologic-Centered ... Ig deposition disease ... #Diagnosis #hematology ... #oncology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
the total white blood ... Disorders: • Chronic myeloid ... myeloid leukemia ... Colitis and Crohn’s Disease ... #hematology #basophils
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
myelodysplastic syndrome • Myeloid ... appearing during the disease ... myelodysplastic #syndrome #differential ... #diagnosis #dermatology ... #oncology #clinical
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Antibodies against myelin-associated ... glycoprotein (MAG) in myelin ... rituximab (in clinical ... Complications #diagnosis ... #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral Infection Clinical ... younger pts) Differential ... Diagnosis Monoclonal ... significance (MGUS), CLL, Myeloma ... hemolytic #anemia #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... et diutinum Neurologic ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Non-Hodgkin's Lymphoma - Comparison ... • Clinical features ... #oncology #diagnosis ... #differential # ... hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
CML (Chronic Myeloid ... • Neutrophils (myeloid ... Myeloid Leukemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
MGUS • Multiple myeloma ... gastric tumors • Hematology ... inflammation (acute ... Gap #ProteinGap #differential ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... cells can indicate disease ... ’s lymphoma or acute ... #workup #oncology ... #hematology
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