32 results
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Clinically ... Relevant HES Variants ... #HES #Hematology ... #eosinophilia # ... #management #algorithm
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia Syndrome ... and Management ... than 1500 and clinical ... #HES #eosinophilia ... #diagnosis #hematology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
of Clinical Significance ... Differential Diagnosis Neurologic-Centered ... capillary leak syndrome ... Ig deposition disease ... Differential #Diagnosis #hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Multiple Myeloma ... and Monoclonal ... ULN R - Renal disease ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
patients with monoclonal ... whom there are no clinical ... concerning for myeloma ... algorithm #diagnosis #management ... #hematology #multiplemyeloma
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... et diutinum Neurologic ... POEMS (Sclerotic myeloma ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology
Eosinophilic Gastroenteritis: Treatment Options Based on Severity of the Disease
Mild:
 • Trial of PPI
 • Trial
Eosinophilic Gastroenteritis ... Severity of the Disease ... + Concern for HES ... : • Hematology ... Gastroenteritis #Treatment #management
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Diagnosis and Management ... lymphoma, multiple myeloma ... thrombocythemia), Autoimmune disease ... #treatment #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
- Idiopathic monoclonal ... Cold Agglutinin Syndrome ... Viral Infection Clinical ... significance (MGUS), CLL, Myeloma ... hemolytic #anemia #hematology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
investigations depending on clinical ... Interstitial nephritis: eosinophilia ... pressure • TTP / HUS ... myoglobin • Myeloma ... Differential #Diagnosis #nephrology