13 results
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Differential Diagnosis ... Non-infectious (malignancy, rheumatologic ... Myelofibrosis • Chronic Myeloid ... Leukemia - BWH ... #Platelets #hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
- Differential ... Diagnosis Secondary ... MF) • Chronic myeloid ... leukemia (CML) ... #hematology #secondary
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Elevated Platelet ... Count - Differential ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... #Platelets #Differential
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
) - Differential ... Diagnosis Neurologic-Centered ... #Differential # ... Diagnosis #hematology ... #oncology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
- Differential ... Diagnosis Algorithm ... Chronic Myelogenous Leukemia ... effect following treatment ... #Causes #Hematology
Hyperviscosity Syndrome - Causes and Treatment

 - Waldenstrom macroglobulinemia (most common) / Plasmapheresis 
 - Multiple
Syndrome - Causes and Treatment ... Plasmapheresis - Multiple myeloma ... Hydroxyurea - Thrombocytosis ... Syndrome #Causes #Differential ... #Diagnosis #Treatment
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
CML (Chronic Myeloid ... (myeloid)↑ • Mature ... basophilia, and thrombocytosis ... #Hematology #Oncology ... #Diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Management Summary myelo ... transformation to acute leukemia ... only curative treatment ... #Management #treatment ... #hematology #oncology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
POEMS (Sclerotic myeloma ... POEMS (Sclerotic myeloma ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
, or all three myeloid ... • Hairy Cell Leukemia ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology