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diagnosis dermatology oncology elevatedmcv generalized hemolysis management pruritus workup agglutinin allergy autoimmune classification cold common cvid disease endocrinology enlarged extravascular
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Hemolytic Anemia ... • Blood smear: Differential ... 2) LOOK FOR a cause ... → Systematic screening ... management #treatment #rheumatology
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Causes of Hemolytic ... Anemia - Differential ... Membrane - Antibody ... #Anemia #Differential ... #hematology
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Algorithm and Causes ... #Hemolytic #Anemia ... #Algorithm #Differential ... #Causes #Workup ... #Hematology #Diagnosis
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Volume (MCV) - Differential ... Diagnosis Algorithm ... Hypersplenism • Secondary ... #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... Diagnosis Algorithm ... Formation • Multiple Myeloma ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential ... malignancies • Anemia ... iron deficiency, hemolysis ... MF) • Chronic myeloid ... #hematology #secondary
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential ... Diagnosis Algorithm ... anemia • ... #Causes #Hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Autoimmune Diseases: • Systemic ... hemoglobinuria • Antibody-mediated ... hemolysis Nutritional ... #Diagnosis #Hematology
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Hyperuricemia - Differential ... Diagnosis Algorithm ... Leukemia (CML) - Hemolytic ... Anemia - Others ... endocrinology #causes
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Diagnosis Algorithm ... Secondary to Inflammation ... #Macrocytosis # ... #Causes #Hematology
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