11 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... Features: POEMS, AL amyloid ... deposits: Ig-related amyloid ... #Significance #MGUS ... Differential #Diagnosis #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Summary Framework Hematologic ... No evidence of anemia ... to IgM multiple myeloma ... insufficiency, Anemia ... to light-chain myeloma
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
patients with monoclonal ... , low-risk MGUS ... concerning for myeloma ... #monoclonal #gammopathy ... diagnosis #management #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• MM • WM • MGUS ... POEMS (Sclerotic myeloma ... POEMS (Sclerotic myeloma ... (-) hemolytic anemia ... Paraproteinemias #Hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Multiple Myeloma ... and Monoclonal ... 40 ml/min A - Anemia ... #Gammopathies #MGUS ... #diagnosis #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
vasculitis • Hematologic ... Abnormalities: macrocytic anemia ... criteria for 1) hematologic ... peripheral blood myeloid ... cells NEJM Review
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... significance (MGUS ... ), CLL, Myeloma ... #hematology #diagnosis
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
Significance (MGUS ... Antibodies against myelin-associated ... glycoprotein (MAG) in myelin ... high-risk situations #MGUS ... Complications #diagnosis #hematology
Indications for Serum Protein Electrophoresis (SPEP)
 • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
Suspected multiple myeloma ... • New-onset anemia ... which multiple myeloma ... • Unexplained pathologic ... Electrophoresis #SPEP #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Gammopathy Include: • MGUS ... • Multiple myeloma ... Smoldering multiple myeloma ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia