11 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
of Clinical Significance ... Features: POEMS, AL amyloid ... #Gammopathy #Clinical ... #Significance # ... Differential #Diagnosis #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
Somatic) Syndrome Clinical ... Syndrome: • Common Clinical ... (12%) • giant cell ... cells NEJM Review ... Autoinflammatory #Somatic #rheumatology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
of Undetermined Significance ... Summary Framework Hematologic ... marrow plasma cells ... #Undetermined #Significance ... #hematology #diagnosis
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
Plasma cell leukemia ... other forms of myeloma ... rouleaux #formation #Clinical ... #Smear #Hematology ... #Pathology
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
patients with monoclonal ... of undetermined significance ... whom there are no clinical ... concerning for myeloma ... diagnosis #management #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral Infection Clinical ... of undetermined significance ... (MGUS), CLL, Myeloma ... sensitize red blood cells ... hemolytic #anemia #hematology
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
of Undetermined Significance ... Antibodies against myelin-associated ... glycoprotein (MAG) in myelin ... rituximab (in clinical ... Complications #diagnosis #hematology
Myeloma: In this BM core, most plasma cells contain cytoplasmic immunoglobulin (Russell bodies).

They're difficult to identify
Myeloma: In this ... core, most plasma cells ... #Myeloma #CD138 ... PlasmaCells #BoneMarrow #Clinical ... #Pathology #Hematology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
occlusions, as well ... than 50 mg/L - Significant ... Biopsy: Typical pathologic ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
clonal plasma cells ... electrophoresis revealed a monoclonal ... #NEJM #clinical ... #radiology #skull ... raindrop #multiple #myeloma