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diagnosis differential management algorithm monoclonal workup mgus leukemia pancytopenia arthritis causes chronic cll hemolytic lymphocytic mds myelodysplastic protein rheumatoid significance
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
alveolitis, ear and ... thromboembolic disease ... Abnormalities: macrocytic anemia ... cells NEJM Review ... Autoinflammatory #Somatic #rheumatology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
capillary leak syndrome ... • Schnitzler syndrome ... Ig deposition disease ... Differential #Diagnosis #hematology ... #oncology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma ... 40 ml/min A - Anemia ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology ... #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... Management Summary myelo ... cytopenias (usually anemia ... Management #treatment #hematology ... #oncology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Formation • Multiple Myeloma ... Myelodysplastic Syndromes ... • Rule out B12 and ... • Liver Disease ... Algorithm #Causes #Hematology
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Multiple Myeloma ... demineralization) • Renal disease ... hypercalcemia) • Anemia ... pathologic fx) ... Diagnosis #Management #oncology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome ... Diagnosis #Algorithm #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Monoclonal Gammopathy ... No evidence of anemia ... insufficiency, Anemia ... #Significance #hematology ... #diagnosis #oncology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Congenital Diseases ... deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Inflammatory and ... Differential #Diagnosis #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... • Symptoms of anemia ... IgM monoclonal gammopathy ... significance (MGUS), CLL, Myeloma ... #hematology #diagnosis
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