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diagnosis management neurology differential syndrome rheumatology endocrinology algorithm clinical nutrition signs symptoms dermatomyositis hematology msk myopathy nephrology rhabdomyolysis summary autoimmune
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... the spinal cord (Myelopathy ... Weakness: - Weakness ... • Infectious causes ... Transverse Myelitis Treatment
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
80%) - Proximal Weakness ... 10%) - Proximal Weakness ... femoral heads • Myopathy ... (Also caused by ... Complications #pathophysiology
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy • Central or peripheral neurologic disease
Causes of Proximal ... Muscle Weakness ... Mimic Inflammatory Myopathy ... Mitochondrial myopathy ... #differential #causes
Causes of Peripheral Weakness - With and Without Sensory Changes - Differential Diagnosis Algorithm With Sensory Changes:
Causes of Peripheral ... Weakness - With ... • No Objective Weakness ... Oculomotor • Myopathy ... Diagnosis #Algorithm #Causes
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Creatine Kinase - Causes ... Elevation (Pain > Weakness ... Subacute to Chronic Causes ... (Weakness > Pain ... PROXIMAL MUSCLE WEAKNESS
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm No Objective Weakness • Cardio-pulmonary disease
Causes of Peripheral ... Weakness without ... No Objective Weakness ... • Congenital Myopathy ... Diagnosis #Algorithm #Causes
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... level of muscle weakness ... and anti-HMGCR myopathy ... have significant weakness ... after 2 years of treatment
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... any time during treatment ... symmetric muscle weakness ... after DC Statin Treatment ... diagnosis #management #treatment
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Weakness • Spinal ... Mitochondrial myopathy ... Neuromuscular #Weakness ... #Causes #differential
Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis •
Generalized Weakness ... I am weak": • Myopathy ... #Generalized #Weakness ... Differential #Diagnosis #causes
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