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diagnosis differential neurology management symptoms algorithm clinical treatment endocrinology rheumatology autoimmune complications dermatomyositis erythematosus hypothyroid lupus msk myositis pathophysiology photo
Myelopathy - Injury to the entire spinal cord - Signs and Symptoms • Ataxia (early sign)
Myelopathy - Injury ... entire spinal cord ... Ataxia (early sign ... • Gross motor weakness ... ) #Myelopathy
Hypothyroidism – symptoms and signs. Symptoms: Tiredness/malaise, Weight gain, Anorexia, Cold intolerance, Poor memory, Change in appearance, Depression, Poor libido,
– symptoms and signs ... gain, Anorexia, Cold ... Signs: Mental ... Carpal timel syndrome ... hypertrophy, Proximal myopathy
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Weakness • Spinal ... Cord: Demyelinating ... Guillain-Barre syndrome ... Mitochondrial myopathy
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... symmetric muscle weakness ... Guillain-Barré syndrome ... antisynthetase syndrome ... (SAMS-CI) • EMG
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... level of muscle weakness ... , holster sign, ... anti-synthetase syndrome ... and anti-HMGCR myopathy
Lesions of the Spinal cord - Spinal Cord Syndromes Spinal cord lesions can result in permanent neurologic
- Spinal Cord Syndromes ... Causes of spinal ... • Extrinsic Causes ... - Infection (e.g ... - Radiation myelopathy
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
• Symptoms and signs ... Causes: 1. ... - Radiation myelopathy ... - Radiation myelopathy ... MCTD, Sjogren syndrome
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
of the spinal cord ... Lack of UMN/LMN signs ... Myopathy: ... mediated necrotizing myopathy ... electromyographic (EMG
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
80%) - Proximal Weakness ... 10%) - Proximal Weakness ... femoral heads • Myopathy ... (Also caused by ... pathophysiology #signs
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm No Objective Weakness • Cardio-pulmonary disease
Causes of Peripheral ... Weakness without ... Lambert-Eaton Myasthenic Syndrome ... • Congenital Myopathy ... Diagnosis #Algorithm #Causes
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