8 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... 80%) - Proximal Weakness ... femoral heads • Myopathy ... (Also caused by ... pathophysiology #signs
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... symmetric muscle weakness ... Guillain-Barré syndrome ... systemic lupus erythematosus ... #diagnosis #management
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
– symptoms and signs ... Myalgia, Muscle weakness ... Carpal timel syndrome ... hypertrophy, Proximal myopathy ... Symptoms #Diagnosis #PhysicalExam
Myoedema in Hypothyroidism on Physical Exam

Hypothyroidism is a clinical syndrome resulting from the production, secretion or
is a clinical syndrome ... and scaly skin, myopathy ... Myopathy due to ... reflex hammer, caused ... Hypothyroidism #PhysicalExam
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... Demyelinating Syndrome ... Aseptic Meningitis, Myelopathy ... autoantibodies that will cause ... cerebritis #diagnosis #management
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
• Symptoms and signs ... Non-compressive Spinal Cord Causes ... - Radiation myelopathy ... - Radiation myelopathy ... MCTD, Sjogren syndrome
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
rapid onset of weakness ... the spinal cord (Myelopathy ... Weakness: - Weakness ... • Bilateral signs ... Myelitis #diagnosis #management
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
NECROTIZING AUTOIMMUNE MYOPATHY ... • If myopathy ... statins - probably caused ... ANTI-MITOCHONDRIAL MYOPATHY ... Autoimmune #Myositis #Myopathy