23 results
diagnosis differential hematology management myopathy erythematosus myositis oncology sle systemic autoimmune classification monoclonal myopathies treatment vasculitis activation algorithm anemia antiphospholipid
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
symmetric muscle weakness ... symmetric muscle weakness ... Anti-retrovirals, Gemcitabine Lupus ... uncommon 5-15% of lupus ... diagnosis #comparison #rheumatology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... 80%) - Proximal Weakness ... femoral heads • Myopathy ... #Systemic #Lupus ... Complications #pathophysiology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic Lupus ... Demyelinating Syndrome ... Aseptic Meningitis, Myelopathy ... Disease, PRES Pathophysiology ... CNS #neurology #rheumatology
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... level of muscle weakness ... anti-synthetase syndrome ... have significant weakness ... Myositis #diagnosis #rheumatology
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... symmetric muscle weakness ... Guillain-Barré syndrome ... GBS), systemic lupus ... antisynthetase syndrome
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Wiskott-Aldrich syndrome ... Diseases: • Systemic lupus ... Differential #Diagnosis #Hematology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
antiphospholipid syndrome ... S - Systemic Lupus ... #differential #hematology
Idiopathic Inflammatory Myopathies (IIM's) RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's) • Overlap Myositis
RASH + MUSCLE WEAKNESS ... antisynthetase syndrome ... Severe proximal weakness ... IIMs #diagnosis #rheumatology ... #dermatology #Myopathy
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... differential #diagnosis #rheumatology
NPSLE - Neurological and Psychiatric Manifestations of Systemic Lupus Erythematosus • Central: Aseptic meningitis, Cerebrovascular disease,
Manifestations of Systemic Lupus ... Demyelinating syndrome ... Seizure disorder, Myelopathy ... Guillain-Barre syndrome ... Erythematosus #SLE #rheumatology
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