19 results
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... symmetric muscle weakness ... , hypothyroid-induced ... syndrome (GBS), ... antisynthetase syndrome
Myelopathy - Injury to the entire spinal cord - Signs and Symptoms
 • Ataxia (early sign)
Myelopathy - Injury ... cord - Signs and Symptoms ... • Gross motor weakness ... early signs) #Myelopathy ... #msk
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
Symptoms: Tiredness ... Myalgia, Muscle weakness ... Carpal timel syndrome ... hypertrophy, Proximal myopathy ... reflexes, Anaemia #Hypothyroid
Myoedema in Hypothyroidism on Physical Exam

Hypothyroidism is a clinical syndrome resulting from the production, secretion or
is a clinical syndrome ... and scaly skin, myopathy ... Myopathy due to ... clinical #video #neurology ... endocrinology #hypothyroid
Symptoms of Hypophosphatemia
 • CNS: Seizures, Delirium, Paresthesias, Central & extrapontine myelinolysis, Hallucinations, Fatigue
 • Hematologic:
Symptoms of Hypophosphatemia ... Bone pain • MSK ... : Proximal myopathy ... Diaphragmatic weakness ... Hypophosphatemia #Phosphate #Symptoms
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... level of muscle weakness ... less systemic symptoms ... anti-synthetase syndrome ... and anti-HMGCR myopathy
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... Demyelinating Disease (MS ... Guillain-Barre syndrome ... Mitochondrial myopathy ... differential #diagnosis #neurology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
80%) - Proximal Weakness ... 10%) - Proximal Weakness ... femoral heads • Myopathy ... Erythematosus #SLE #MSK ... pathophysiology #signs #symptoms
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
• Acute stroke syndromes ... Myopathy: ... mediated necrotizing myopathy ... Endocrinopathies: Hypothyroid ... Differential #Diagnosis #neurology
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
of Peripheral Weakness ... No Objective Weakness ... Lambert-Eaton Myasthenic Syndrome ... • Congenital Myopathy ... #Neurology #Differential