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diagnosis signs differential management neurology pathophysiology algorithm rheumatology causes clinical treatment endocrinology msk syndromes hematology cardiology gastroenterology physicalexam criteria oncology
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
findings: • Symptoms ... /paralysis - Weakness ... - Radiation myelopathy ... - Radiation myelopathy ... MCTD, Sjogren syndrome
Lesions of the Spinal cord - Spinal Cord Syndromes Spinal cord lesions can result in permanent neurologic
findings: - Weakness ... Lower motor neuron symptoms ... Upper motor neuron symptoms ... result in: - Weakness ... - Radiation myelopathy
Cauda Equina Syndrome Overview Cauda Equina Syndrome: • Prevalence: 1:33,000-100,000 ppl/yr • Incidence: 1.5-3.4 million ppl/yr •
Cauda Equina Syndrome ... spine L1-L5 Symptoms ... so-called ‘red flag’ symptoms ... • HIV related myelopathy ... lower extremity weakness
Myelopathy - Injury to the entire spinal cord - Signs and Symptoms • Ataxia (early sign)
Myelopathy - Injury ... cord - Signs and Symptoms ... • Gross motor weakness ... early signs) #Myelopathy ... diagnosis #signs #symptoms
Hypothyroidism – symptoms and signs. Symptoms: Tiredness/malaise, Weight gain, Anorexia, Cold intolerance, Poor memory, Change in appearance, Depression, Poor libido,
Hypothyroidism – symptoms ... Symptoms: Tiredness ... Myalgia, Muscle weakness ... Carpal timel syndrome ... hypertrophy, Proximal myopathy
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... symmetric muscle weakness ... Guillain-Barré syndrome ... antisynthetase syndrome ... Lambert-Eaton myasthenic syndrome
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... level of muscle weakness ... less systemic symptoms ... anti-synthetase syndrome ... have significant weakness
Neurological Patterns of Weakness • Hemispheric lesion • Brainstem lesion • Spinal cord lesion • Polyneuropathy
Neurological Patterns of Weakness ... Polyneuropathy • Myopathy ... Neurology #Patterns #Weakness
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
symmetric muscle weakness ... symmetric muscle weakness ... Fever, No muscle weakness ... asymmetric muscle weakness ... Proximal muscle weakness
Myositis and Myopathies #ESR #CK #Differential diagnosis of myopathy #Inflammatory #myopathies #Dermatomyositis #muscle weakness #Polymyositis #Inclusion body myositis #Polymyalgia rheumatica #Fibromyalgia #Hypothyroid myopathy #Muscle stiffness #Drug-induced
Differential diagnosis of myopathy ... Dermatomyositis #muscle weakness ... #Hypothyroid myopathy ... Statin-induced myopathy ... Cocaine-induced myopathy
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