108 results
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
#Differential diagnosis ... of myopathy # ... #Dermatomyositis ... #Hypothyroid myopathy ... Statin-induced myopathy
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Anti-Jo, +Anti-Mi2 Dermatomyositis ... load Drug-induced myopathy ... 5-15% of lupus myopathy ... #myopathy #differential ... #diagnosis #comparison
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Inflammatory myopathy ... polymyositis, dermatomyositis ... Statin-induced myopathy ... Atorvastatin Diagnosis ... #diagnosis #management
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Critical Illness Myopathy ... - Inflammatory myopathy ... : dermatomyositis ... polymyositis, necrotizing myopathy ... #differential #diagnosis
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... Dermatomyositis ... /full triad at diagnosis ... and anti-HMGCR myopathy ... Autoimmune #Myositis #diagnosis
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Antibodies (MSAs) Dermatomyositis ... Mediated Necrotizing Myopathy ... MSAs #clinical #diagnosis
Cutaneous and Systemic Findings in Dermatomyositis
Cutaneous Findings:
 - Heliotrope sign and edema
 - Nail-fold changes
 -
Systemic Findings in Dermatomyositis ... , inflammatory myopathy ... Findings #Signs #Dermatomyositis ... #Diagnosis #Rheumatology
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
- Differential Diagnosis ... • Congenital Myopathy ... Statin Toxicity • Dermatomyositis ... #Differential #Diagnosis
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Mitochondrial myopathy ... , Polymyositis/dermatomyositis ... #differential #diagnosis
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... NECROTIZING AUTOIMMUNE MYOPATHY ... syndrome • If myopathy ... ANTI-MITOCHONDRIAL MYOPATHY ... Autoimmune #Myositis #Myopathy