1381 results
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
Hypothyroid Myopathy ... Symmetric, proximal myopathy ... #Hypothyroid #Myopathy ... pathophysiology #signs
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... heliotrope rash, Shaw sign ... , holster sign, ... and anti-HMGCR myopathy
Cutaneous and Systemic Findings in Dermatomyositis
Cutaneous Findings:
 - Heliotrope sign and edema
 - Nail-fold changes
 -
- Heliotrope sign ... or shawl sign ... - Gottron's sign ... scale - Holster sign ... , inflammatory myopathy
Symptoms of Hypophosphatemia
 • CNS: Seizures, Delirium, Paresthesias, Central & extrapontine myelinolysis, Hallucinations, Fatigue
 • Hematologic:
MSK: Proximal myopathy ... Phosphate #Symptoms #Signs
Hyperthyroidism – symptoms and signs. 

Symptoms:

Weight loss, Increased appetite, Irritability/behaviour change, Restlessness, Malaise, Stiffness, Muscle weakness,
– symptoms and signs ... ), Sweating Signs ... loss, Proximal myopathy ... Hyperthyroidism #Symptoms #Signs
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
femoral heads • Myopathy ... pathophysiology #signs
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
– symptoms and signs ... , Deafness Signs ... hypertrophy, Proximal myopathy ... Hypothyroid #Features #Signs
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Lack of UMN/LMN signs ... proximal weakness Myopathy ... mediated necrotizing myopathy ... • Metabolic myopathies ... certain drug-induced myopathies
Clinical Effects of Large and Small Pituitary Tumours
Local complications - Headache, Visual field defect, Disconnection hyperprolactinaemia,
gain, Bruising, Myopathy ... Pituitary #Tumors #Signs
Dermatomyositis
A middle-aged man describes progressive difficulty combing his hair and rising from a seated position over
rash, 2) shawl sign ... usually indicates myopathy