27 results
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... symmetric muscle weakness ... such as • Statin-induced ... Atorvastatin Diagnosis ... #diagnosis #management
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... level of muscle weakness ... , holster sign, ... anti-synthetase syndrome ... and anti-HMGCR myopathy
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
– symptoms and signs ... Myalgia, Muscle weakness ... Carpal timel syndrome ... hypertrophy, Proximal myopathy ... #Symptoms #Diagnosis
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
Any inflammatory myopathy ... antisynthetase syndrome ... Inflammatory myopathy ... #IIMs #diagnosis ... #dermatology #Myopathy
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... Motor Nerves: ALS ... Guillain-Barre syndrome ... Mitochondrial myopathy ... #differential #diagnosis
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Diagnosis Framework ... Lack of UMN/LMN signs ... Myopathy: ... mediated necrotizing myopathy ... #Differential #Diagnosis
Symptoms of Hypophosphatemia
 • CNS: Seizures, Delirium, Paresthesias, Central & extrapontine myelinolysis, Hallucinations, Fatigue
 • Hematologic:
MSK: Proximal myopathy ... Diaphragmatic weakness ... Phosphate #Symptoms #Signs ... #Diagnosis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
80%) - Proximal Weakness ... 10%) - Proximal Weakness ... femoral heads • Myopathy ... pathophysiology #signs ... #symptoms #diagnosis
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
Generalized Weakness ... - Differential Diagnosis ... I am weak": • Myopathy ... Polyneuropathy, ALS ... #Generalized #Weakness
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
of Peripheral Weakness ... - Differential Diagnosis ... Lambert-Eaton Myasthenic Syndrome ... • Congenital Myopathy ... #Differential #Diagnosis